Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.62 |
| ▸ | BRAF | P15056 | 18/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | FLT1 | P17948 | 2/20 | 0.57 |
| ▸ | FLT4 | P35916 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796201 | 0.92 | RAF1 (0.70) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13504248 | 0.91 | RAF1 (0.69) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13504302 | 0.87 | BRAF (0.76) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13559578 | 0.85 | RAF1 (0.67) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2892052 | 0.82 | RAF1 (0.70) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13504311 | 0.81 | RAF1 (0.55) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13504220 | 0.81 | BRAF (0.84) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13504237 | 0.81 | BRAF (0.76) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL13559583 | 0.81 | BRAF (0.84) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2891684 | 0.81 | BRAF (0.76) | RAF1BRAFKDRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675584-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE | CHIRON CORPORATION (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005032548-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE | CHIRON CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |