Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 7/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.36 |
| ▸ | PIK3R5 | Q8WYR1 | 7/20 | 0.36 |
| ▸ | PIK3R3 | Q92569 | 7/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5810315 | 0.88 | JAK2 (0.39) | JAK3JAK2JAK1EGFRRET | |
| SCHEMBL5812791 | 0.83 | EGFR (0.42) | JAK3JAK2BTKEGFRRET | |
| SCHEMBL4818423 | 0.83 | JAK2 (0.56) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL4818418 | 0.83 | JAK2 (0.56) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL6246222 | 0.81 | KAT2B (0.36) | JAK3JAK2JAK1TYK2BTK | |
| Acetic Acid SCHEMBL4819303 | 0.78 | JAK3 (0.58) | JAK3JAK2JAK1TYK2BTK | |
| Acetic Acid SCHEMBL4819297 | 0.78 | JAK3 (0.58) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL4818634 | 0.76 | JAK2 (0.54) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL5818829 | 0.76 | GAA (0.47) | JAK3JAK2JAK1BTKEGFR | |
| SCHEMBL5814297 | 0.75 | RET (0.39) | JAK3JAK2BTKEGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |