Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.80 |
| ▸ | AKT2 | P31751 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | ILK | Q13418 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132051 | 0.91 | MAPK1 (0.83) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL6132080 | 0.89 | MAPK1 (0.80) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL6132076 | 0.89 | MAPK1 (0.80) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL6132022 | 0.89 | MAPK1 (0.80) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL6132067 | 0.89 | MAPK1 (0.80) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL8640607 | 0.85 | MAPK1 (0.73) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL6132033 | 0.83 | MAPK1 (0.70) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL6132021 | 0.83 | MAPK1 (0.70) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL6132090 | 0.83 | MAPK1 (0.70) | MAPK1NPSR1RPS6KA3AKT2KMT2A | |
| SCHEMBL2949076 | 0.81 | KDM4E (0.68) | MAPK1NPSR1RPS6KA3AKT2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006131807-A1 | PREPARATION OF 3-AMINO-4,5-DISUBSTITUTED-PYRAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2006-12-14 | — | — | WO | disclosed |