SCHEMBL5820136

SCHEMBL5820136

CCOc1ccc(C(=O)C(=O)Nc2cc(C(C)(C)C)cc(NS(C)(=O)=O)c2OC)c2ccccc12

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCARB1 Q8WTV0 12/20 0.77
MAPK14 Q16539 8/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1600035 0.92 SCARB1 (0.74) SCARB1MAPK14
SCHEMBL1600480 0.91 SCARB1 (0.79) SCARB1MAPK14
SCHEMBL12669833 0.91 SCARB1 (0.76) SCARB1MAPK14
SCHEMBL1600378 0.91 SCARB1 (0.78) SCARB1MAPK14
SCHEMBL1599815 0.89 SCARB1 (0.87) SCARB1MAPK14
SCHEMBL12669836 0.89 SCARB1 (0.76) SCARB1MAPK14
SCHEMBL1600168 0.89 SCARB1 (0.84) SCARB1MAPK14
SCHEMBL4947564 0.88 SCARB1 (0.74) SCARB1MAPK14
SCHEMBL12669914 0.87 SCARB1 (0.75) SCARB1MAPK14
SCHEMBL1905008 0.87 SCARB1 (1.00) SCARB1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006091862-A2 CYTOKINE INHIBITORS AND THEIR USE IN THERAPY KEMIA, INC. (US) 2006-08-31 WO disclosed