Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.52 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13562966 | 0.90 | BTK (0.57) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5817678 | 0.89 | BTK (0.59) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL22902484 | 0.87 | BTK (0.55) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5815559 | 0.86 | BTK (0.54) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5817781 | 0.86 | BTK (0.54) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL23216900 | 0.84 | BTK (0.58) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5803516 | 0.83 | BTK (0.78) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL29665749 | 0.83 | BTK (0.78) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5817903 | 0.83 | TNK2 (0.54) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL22902483 | 0.83 | BTK (0.52) | BTKLCKLYNNUDT14NUDT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |