Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 12/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820118 | 0.88 | BRAF (0.73) | CDKN1ABRAF | |
| SCHEMBL5821447 | 0.87 | CDKN1A (0.67) | KDM4ECDKN1ABRAFTLR8 | |
| SCHEMBL7367250 | 0.87 | KDM4E (0.67) | KDM4ECDKN1ABRAFTLR8 | |
| SCHEMBL5800515 | 0.86 | CDKN1A (0.66) | KDM4ECDKN1ABRAF | |
| SCHEMBL7361109 | 0.85 | KDM4E (0.74) | KDM4EBRAFTLR8 | |
| SCHEMBL5796875 | 0.85 | CDKN1A (0.67) | KDM4ECDKN1ABRAFTLR8 | |
| SCHEMBL5807609 | 0.85 | CDKN1A (0.67) | KDM4ECDKN1ABRAFTLR8 | |
| SCHEMBL5823332 | 0.85 | CDKN1A (0.67) | KDM4ECDKN1ABRAFTLR8 | |
| SCHEMBL7365326 | 0.85 | KDM4E (0.67) | KDM4ECDKN1ABRAFTLR8 | |
| SCHEMBL7366563 | 0.85 | KDM4E (0.67) | KDM4ECDKN1ABRAFTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | claimed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | claimed |
| WO-2006033795-A2 | SUBSTITUTED PYRAZOLO [1, 5-A] PYRIMIDINES FOR INHIBITING ABNORMAL CELL GROWTH | WYETH (US) | 2006-03-30 | — | — | WO | disclosed |