Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 11/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799423 | 0.84 | TP53 (0.48) | GSK3AMAPK13PIM1EPHA2BRAF | |
| SCHEMBL4762128 | 0.84 | BRAF (0.56) | MAPK13PIM1BRAFKDR | |
| SCHEMBL4656907 | 0.83 | BRAF (0.69) | BRAF | |
| SCHEMBL4658179 | 0.82 | BRAF (0.62) | BRAF | |
| SCHEMBL10733510 | 0.82 | GSK3A (0.59) | GSK3AMAPK13PIM1EPHA2BRAF | |
| SCHEMBL5808332 | 0.82 | BRAF (0.49) | MAPK13PIM1BRAFKDR | |
| SCHEMBL4655778 | 0.81 | BRAF (0.76) | BRAF | |
| SCHEMBL4658290 | 0.80 | BRAF (0.71) | BRAFKDR | |
| SCHEMBL4656125 | 0.80 | BRAF (0.74) | BRAF | |
| SCHEMBL5622067 | 0.80 | BRAF (0.71) | BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006033795-A2 | SUBSTITUTED PYRAZOLO [1, 5-A] PYRIMIDINES FOR INHIBITING ABNORMAL CELL GROWTH | WYETH (US) | 2006-03-30 | — | — | WO | claimed |