Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823170 | 0.90 | CSNK1D (0.46) | MAPK14CDK2MAPK1MAPK8PRKD3 | |
| SCHEMBL5819235 | 0.90 | BRAF (0.51) | BRAFCDK2CCNA2MAPK9 | |
| SCHEMBL5818628 | 0.89 | BRAF (0.47) | BRAFROCK2CDK2CCNA2 | |
| SCHEMBL5818779 | 0.86 | MAPK9 (0.48) | BRAFMAPK14CDK2CCNA2MAPK9 | |
| SCHEMBL5819127 | 0.86 | BRAF (0.44) | BRAFROCK2CDK2CCNA2RAF1 | |
| SCHEMBL5815121 | 0.86 | BRAF (0.50) | BRAFROCK2MAPK14MAPK1RAF1 | |
| SCHEMBL5819379 | 0.86 | MAPK9 (0.48) | BRAFCDK2CCNA2MAPK9 | |
| SCHEMBL5814974 | 0.83 | BRAF (0.47) | BRAFROCK2RAF1MAPK8MAPK9 | |
| SCHEMBL5814640 | 0.82 | BRAF (0.47) | BRAFMAPK14CDK2MAPK1RAF1 | |
| SCHEMBL5814884 | 0.80 | SYK (0.40) | BRAFMAPK14CDK2CCNA2MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |