Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 8/20 | 1.00 |
| ▸ | GSK3B | P49841 | 8/20 | 1.00 |
| ▸ | MAPK6 | Q16659 | 10/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 5/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819986 | 0.90 | GSK3A (0.81) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5820264 | 0.89 | GSK3A (0.80) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5806576 | 0.88 | GSK3A (0.79) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5823133 | 0.87 | GSK3A (0.77) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5820761 | 0.86 | GSK3A (0.76) | GSK3AGSK3BMAPK6AURKAMAPK14 | |
| SCHEMBL5806572 | 0.86 | MAPK6 (0.77) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL16012808 | 0.86 | MAPK6 (0.81) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5820508 | 0.86 | GSK3A (0.75) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL16012652 | 0.86 | MAPK6 (0.81) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5818337 | 0.86 | MAPK6 (0.81) | GSK3AGSK3BMAPK6MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |