Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464722 | 0.93 | KCNH2 (0.34) | KCNH2 | |
| SCHEMBL5464559 | 0.93 | JAK2 (0.37) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL5462261 | 0.86 | KCNH2 (0.34) | KCNH2 | |
| SCHEMBL5465125 | 0.85 | JAK2 (0.37) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL5820914 | 0.84 | KCNH2 (0.40) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL5453133 | 0.84 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL5461882 | 0.83 | KCNH2 (0.43) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL5458030 | 0.81 | KCNH2 (0.37) | KCNH2 | |
| SCHEMBL5450730 | 0.81 | JAK2 (0.38) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL5801958 | 0.81 | JAK2 (0.35) | JAK2JAK1TYK2JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687296-A1 | ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES | Warner-Lambert Company LLC (US) | 2006-08-09 | — | — | EP | claimed |
| WO-2005049605-A1 | ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-02 | — | — | WO | claimed |