Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | CCR4 | P51679 | 7/20 | 0.40 |
| ▸ | ERN1 | O75460 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823637 | 0.91 | SGK1 (0.42) | SGK1KITCCR4ERN1ACLY | |
| SCHEMBL5803133 | 0.89 | CCR4 (0.49) | SGK1KITCCR4MAPK14 | |
| SCHEMBL5822848 | 0.86 | SGK1 (0.44) | SGK1KITCCR4ERN1ACLY | |
| SCHEMBL5822181 | 0.85 | SGK1 (0.46) | SGK1KITCCR4ERN1ACLY | |
| SCHEMBL5823869 | 0.83 | SGK1 (0.46) | SGK1KITCCR4ERN1ACLY | |
| SCHEMBL24429612 | 0.82 | KIT (0.46) | SGK1KITERN1 | |
| SCHEMBL6430312 | 0.82 | KIT (0.44) | SGK1KITCCR4 | |
| SCHEMBL5804448 | 0.82 | CCR4 (0.53) | SGK1KITCCR4 | |
| SCHEMBL6433271 | 0.80 | CCR4 (0.47) | SGK1KITCCR4ERN1 | |
| SCHEMBL6430815 | 0.79 | CCR4 (0.57) | SGK1KITCCR4ACLYPTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |