Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MMP2 | P08253 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | MITF | O75030 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | ASF1A | Q9Y294 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812859 | 1.00 | KDM1A (0.66) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL5812856 | 1.00 | KDM1A (0.66) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL20588127 | 0.91 | KMT2A (0.76) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL20588125 | 0.91 | KMT2A (0.76) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL22179534 | 0.91 | KMT2A (0.76) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL12387718 | 0.91 | GCGR (0.65) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL684807 | 0.90 | MAPT (0.64) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL684783 | 0.90 | KDM1A (0.82) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL686241 | 0.89 | PHGDH (0.67) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL17967182 | 0.88 | KDM1A (0.56) | KDM1ARAB9ANPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | claimed |
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | disclosed |