Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.68 |
| ▸ | RET | P07949 | 2/20 | 0.68 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.68 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.68 |
| ▸ | EPHA4 | P54764 | 2/20 | 0.68 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.68 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.68 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.68 |
| ▸ | ADK | P55263 | 1/20 | 0.68 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.68 |
| ▸ | MET | P08581 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29781334 | 0.96 | EGFR (0.78) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL2456578 | 0.96 | EGFR (0.78) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL202067 | 0.96 | EGFR (0.78) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL13604778 | 0.94 | EGFR (0.66) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL5821251 | 0.92 | EGFR (0.72) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL6436466 | 0.92 | EGFR (0.74) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL3132903 | 0.92 | EGFR (0.74) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL3132783 | 0.92 | EGFR (0.74) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL5210047 | 0.91 | EGFR (0.85) | EGFRERBB2RIPK2RETEPHB2 | |
| SCHEMBL3966911 | 0.89 | EGFR (0.77) | EGFRERBB2RIPK2RETEPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670782-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028470-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | disclosed |