Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.44 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803241 | 0.90 | BTK (0.61) | BTKEGFRKITFLT3LCK | |
| SCHEMBL6465778 | 0.85 | BTK (0.56) | BTKEGFRKITFLT3LCK | |
| SCHEMBL5823166 | 0.84 | BTK (0.65) | BTKEGFRKITFLT3LCK | |
| SCHEMBL6433565 | 0.82 | BTK (0.61) | BTKEGFRKITFLT3LCK | |
| SCHEMBL21966559 | 0.79 | BTK (0.59) | BTKEGFRKITFLT3LCK | |
| SCHEMBL6641514 | 0.78 | BTK (0.56) | BTKEGFRLCKNUDT14NUDT5 | |
| SCHEMBL6430393 | 0.76 | BTK (0.69) | BTKEGFRKITFLT3LCK | |
| SCHEMBL1568925 | 0.76 | BTK (0.79) | BTKEGFRLCKITK | |
| SCHEMBL5823933 | 0.76 | BTK (0.49) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL21903500 | 0.76 | BTK (0.62) | BTKEGFRLCKITKNUDT14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |