Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1268279 | 0.89 | MAPT (0.85) | MAPTTP53SMN1; SMN2MEN1HTT | |
| SCHEMBL30445827 | 0.89 | MAPT (0.65) | MAPTTP53SMN1; SMN2MEN1HTT | |
| SCHEMBL29373842 | 0.89 | MAPT (0.65) | MAPTTP53SMN1; SMN2MEN1HTT | |
| SCHEMBL10063837 | 0.89 | MAPT (0.65) | MAPTTP53SMN1; SMN2MEN1HTT | |
| SCHEMBL5818804 | 0.88 | MAPT (0.56) | MAPTTP53SMN1; SMN2MEN1HTT | |
| SCHEMBL5822835 | 0.87 | MAPT (0.58) | MAPTTP53SMN1; SMN2MEN1HTT | |
| SCHEMBL13679611 | 0.84 | MEN1 (0.74) | MAPTTP53MEN1HTTKMT2A | |
| SCHEMBL13679601 | 0.83 | MAPT (0.82) | MAPTTP53MEN1HTTKMT2A | |
| SCHEMBL12831265 | 0.82 | MAPT (0.73) | MAPTTP53MEN1HTTKMT2A | |
| SCHEMBL14642442 | 0.81 | MEN1 (0.79) | MAPTTP53MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124780-A2 | IH-BENZO [D] IMIDAZOLE COMPOUNDS AS INHIBITORS OF B-RAF KINASE | KALYPSYS, INC. (US) | 2006-11-23 | — | — | WO | disclosed |