Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.57 |
| ▸ | KDR | P35968 | 6/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819541 | 0.93 | KDR (0.54) | FGFR1FGFR2FGFR3KDRAURKB | |
| SCHEMBL5816678 | 0.92 | FGFR1 (0.53) | FGFR1FGFR2FGFR3KDRAURKB | |
| SCHEMBL5816340 | 0.92 | FGFR1 (0.53) | FGFR1FGFR2FGFR3KDRAURKB | |
| SCHEMBL5819066 | 0.90 | KDR (0.51) | FGFR1FGFR2FGFR3KDRPDGFRB | |
| SCHEMBL5823306 | 0.90 | FGFR1 (0.61) | FGFR1FGFR2FGFR3KDRNTRK1 | |
| SCHEMBL5819717 | 0.90 | FGFR1 (0.61) | FGFR1FGFR2FGFR3KDRNTRK1 | |
| SCHEMBL5815284 | 0.89 | FGFR1 (0.64) | FGFR1FGFR2FGFR3KDRNTRK1 | |
| SCHEMBL5817149 | 0.89 | FGFR1 (0.52) | FGFR1FGFR2FGFR3KDRAURKB | |
| SCHEMBL5819689 | 0.89 | FGFR1 (0.61) | FGFR1FGFR2FGFR3KDRNTRK1 | |
| SCHEMBL5817863 | 0.89 | FGFR1 (0.61) | FGFR1FGFR2FGFR3KDRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | claimed |
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | disclosed |