Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823187 | 1.00 | CHRM3 (0.58) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL9357167 | 0.93 | KCNH2 (0.66) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL9357165 | 0.93 | KCNH2 (0.66) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL5807614 | 0.92 | CHRM3 (0.60) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL5807618 | 0.92 | CHRM3 (0.60) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL5808113 | 0.90 | CHRM3 (0.59) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL5808110 | 0.90 | CHRM3 (0.59) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL5803627 | 0.89 | CHRM3 (0.61) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL5803628 | 0.89 | CHRM3 (0.61) | CHRM3KCNH2CHRM2CHRM1ADRB2 | |
| SCHEMBL5805203 | 0.89 | CHRM3 (0.58) | CHRM3KCNH2CHRM2CHRM1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006097848-A1 | HIV-1 VIRION MATURATION INHIBITORS, COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-09-21 | — | — | WO | disclosed |
| US-5932594-A | Muscarinic receptor antagonists | PFIZER, INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0441852-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 1997-05-14 | — | — | EP | disclosed |
| US-5422358-A | Muscarinic receptor antagonists | PFIZER INC (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0376358-A1 | Muscarinic receptor antagonists | PFIZER INC. (US) | 1990-07-04 | — | — | EP | disclosed |