Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | CDK1 | P06493 | 3/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | WNT1 | P04628 | 4/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | CLK3 | P49761 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042919 | 0.98 | RET (0.59) | RETKDRCDK1ERBB2WNT1 | |
| SCHEMBL4038126 | 0.90 | RET (0.69) | RETKDRCDK1ERBB2WNT1 | |
| SCHEMBL4033966 | 0.87 | RET (0.70) | RETKDRCDK1ERBB2WNT1 | |
| SCHEMBL4038916 | 0.87 | RET (0.68) | RETKDRCDK1ERBB2WNT1 | |
| SCHEMBL4036833 | 0.86 | RET (0.70) | RETKDRCDK1ERBB2WNT1 | |
| SCHEMBL4039916 | 0.85 | RET (0.54) | RETKDRCDK1ERBB2WNT1 | |
| SCHEMBL4039901 | 0.85 | RET (0.70) | RETKDRCDK1ERBB2WNT1 | |
| SCHEMBL4042953 | 0.85 | RET (0.62) | RETKDRCDK1ERBB2WNT1 | |
| Isopropylamine SCHEMBL5823529 | 0.84 | RET (0.68) | RETKDRCDK1ERBB2WNT1 | |
| SCHEMBL4037196 | 0.84 | RET (0.72) | RETKDRCDK1ERBB2WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006130673-A1 | 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |