Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.62 |
| ▸ | CDK1 | P06493 | 4/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | CLK2 | P49760 | 5/20 | 0.50 |
| ▸ | CLK3 | P49761 | 5/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.50 |
| ▸ | WNT1 | P04628 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 4/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038630 | 0.97 | RET (0.65) | RETERBB2CDK1KDRCLK2 | |
| SCHEMBL5823388 | 0.91 | RET (0.65) | RETERBB2CDK1KDRCLK2 | |
| SCHEMBL4039564 | 0.91 | RET (0.66) | RETERBB2CDK1KDRCLK2 | |
| SCHEMBL4035297 | 0.90 | RET (0.68) | RETERBB2CDK1KDRCLK2 | |
| SCHEMBL13797844 | 0.89 | RET (0.64) | RETERBB2CDK1KDRCLK2 | |
| SCHEMBL4033805 | 0.87 | RET (0.53) | RETERBB2CDK1KDRCLK2 | |
| SCHEMBL13797846 | 0.86 | CDK1 (0.63) | RETERBB2CDK1KDRCLK2 | |
| Isopropylamine SCHEMBL5823492 | 0.86 | RET (0.51) | RETERBB2CDK1KDRCLK2 | |
| SCHEMBL4039588 | 0.86 | RET (0.48) | RETERBB2CDK1KDRCLK2 | |
| SCHEMBL5823407 | 0.85 | RET (0.46) | RETERBB2CDK1KDRCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006130673-A1 | 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |