Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 7/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | SGK1 | O00141 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | EIF2AK3 | Q9NZJ5 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804448 | 0.90 | CCR4 (0.53) | CCR4KITSGK1RIPK1PIK3CD | |
| SCHEMBL5803133 | 0.88 | CCR4 (0.49) | CCR4KITSGK1RIPK1PIK3CD | |
| SCHEMBL6433271 | 0.88 | CCR4 (0.47) | CCR4KITSGK1ERN1RIPK1 | |
| SCHEMBL6433439 | 0.87 | CCR4 (0.55) | CCR4KITSGK1RIPK1PIK3CD | |
| SCHEMBL6430815 | 0.87 | CCR4 (0.57) | CCR4KITSGK1RIPK1PIK3CD | |
| SCHEMBL6433539 | 0.85 | CCR4 (0.46) | CCR4KITSGK1ERN1RIPK1 | |
| SCHEMBL6432915 | 0.84 | CCR4 (0.43) | CCR4KITSGK1ERN1RIPK1 | |
| SCHEMBL6432129 | 0.84 | CCR4 (0.43) | CCR4KITSGK1ERN1RIPK1 | |
| SCHEMBL5822845 | 0.84 | CCR4 (0.47) | CCR4KITSGK1RIPK1PIK3CD | |
| SCHEMBL6433014 | 0.83 | CCR4 (0.45) | CCR4KITSGK1ERN1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |