Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.43 |
| ▸ | NR2C2 | P49116 | 3/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644392 | 0.89 | AGPAT2 (0.51) | BRAFRAF1P2RX3MAPT | |
| SCHEMBL1644406 | 0.79 | AGPAT2 (0.54) | BRAFRAF1P2RX3MAPT | |
| SCHEMBL3119465 | 0.78 | AGPAT2 (0.53) | BRAFRAF1P2RX3MAPTIKBKB | |
| Hydrochloric Acid SCHEMBL3123797 | 0.78 | AGPAT2 (0.53) | BRAFRAF1P2RX3MAPT | |
| SCHEMBL3119649 | 0.78 | BRAF (0.58) | BRAFRAF1NFKB1NR2C2NFKB2 | |
| SCHEMBL1643684 | 0.77 | AGPAT2 (0.49) | BRAFRAF1MAPT | |
| SCHEMBL1642641 | 0.77 | AGPAT2 (0.47) | BRAFRAF1P2RX3MAPTIKBKB | |
| SCHEMBL22737611 | 0.76 | GCK (0.56) | BRAFRAF1 | |
| SCHEMBL1644365 | 0.76 | AGPAT2 (0.45) | BRAFRAF1MAPT | |
| SCHEMBL1643674 | 0.75 | MCL1 (0.47) | BRAFP2RX3MAPTIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689722-A2 | 4-AMINOPYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS | Bayer Pharmaceuticals Corporation (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005035507-A2 | 4-AMINOPYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-04-21 | — | — | WO | disclosed |