Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470737 | 0.94 | CHEK1 (0.55) | CHEK1 | |
| SCHEMBL5824018 | 0.88 | CHEK1 (0.52) | CHEK1 | |
| SCHEMBL5470906 | 0.86 | CHEK1 (0.58) | CHEK1 | |
| SCHEMBL5477816 | 0.84 | CHEK1 (0.51) | CHEK1 | |
| SCHEMBL5470383 | 0.82 | CHEK1 (0.74) | CHEK1 | |
| SCHEMBL5478959 | 0.81 | CHEK1 (0.46) | CHEK1 | |
| SCHEMBL5480599 | 0.79 | CHEK1 (0.55) | CHEK1 | |
| SCHEMBL5472703 | 0.78 | CHEK1 (0.47) | CHEK1 | |
| SCHEMBL5480669 | 0.77 | CHEK1 (0.62) | CHEK1 | |
| SCHEMBL5478058 | 0.75 | CHEK1 (0.63) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613625-A1 | NOVEL FUSED TRIAZOLONES AND THE USES THEREOF | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004081008-A1 | NOVEL FUSED TRIAZOLONES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |