Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5826041 | 0.90 | SRC (0.55) | SRCTGFBR1AXLPDGFRAFGFR2 | |
| SCHEMBL5825603 | 0.90 | SRC (0.56) | SRCTGFBR1AXLPDGFRAFGFR2 | |
| SCHEMBL5825740 | 0.87 | SRC (0.51) | SRCTGFBR1AXLPDGFRAFGFR2 | |
| SCHEMBL5825172 | 0.87 | SRC (0.56) | SRCTGFBR1PDGFRAFGFR2KDR | |
| SCHEMBL5825663 | 0.84 | FGFR2 (0.56) | SRCTGFBR1PDGFRAFGFR2KDR | |
| SCHEMBL5825396 | 0.84 | SRC (0.55) | SRCTGFBR1PDGFRAKDR | |
| SCHEMBL5826139 | 0.84 | SRC (0.55) | SRCTGFBR1PDGFRAKDRKIT | |
| SCHEMBL5825521 | 0.83 | SRC (0.53) | SRCTGFBR1PDGFRAFGFR2KDR | |
| SCHEMBL5825526 | 0.83 | PDGFRA (0.56) | AXLPDGFRAFGFR2KDRKIT | |
| SCHEMBL5825716 | 0.81 | SRC (0.52) | SRCTGFBR1PDGFRAKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | claimed |