Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | BRAF | P15056 | 10/20 | 0.49 |
| ▸ | RAF1 | P04049 | 8/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828139 | 1.00 | EGFR (0.50) | EGFRBRAFRAF1KDRRET | |
| SCHEMBL5828886 | 0.94 | PDGFRB (0.49) | EGFRBRAFRAF1KDRRET | |
| SCHEMBL5828882 | 0.94 | PDGFRB (0.49) | EGFRBRAFRAF1KDRRET | |
| SCHEMBL5828689 | 0.92 | EGFR (0.52) | EGFRBRAFRAF1KDRRET | |
| SCHEMBL5828691 | 0.92 | EGFR (0.52) | EGFRBRAFRAF1KDRRET | |
| SCHEMBL6982367 | 0.88 | EGFR (0.55) | EGFRBRAFKDRRETAURKA | |
| SCHEMBL5828456 | 0.85 | KDR (0.53) | EGFRBRAFRAF1KDRRET | |
| SCHEMBL5828454 | 0.85 | KDR (0.53) | EGFRBRAFRAF1KDRRET | |
| SCHEMBL5828257 | 0.85 | PDGFRB (0.52) | EGFRBRAFKDRRETPDGFRB | |
| SCHEMBL5828263 | 0.85 | PDGFRB (0.52) | EGFRBRAFKDRRETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |