Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582366 | 0.98 | PDE4B (0.51) | PDE4BPDE7APDE4D | |
| Bicarbonate SCHEMBL587811 | 0.98 | PDE4B (0.49) | PDE4BPDE7APDE4D | |
| Bicarbonate SCHEMBL582972 | 0.93 | PDE4B (0.54) | PDE4BPDE7APDE4D | |
| SCHEMBL582555 | 0.93 | PDE4B (0.51) | PDE4BPDE7APDE4D | |
| Bicarbonate SCHEMBL583381 | 0.92 | PDE4B (0.48) | PDE4BPDE7APDE4D | |
| SCHEMBL582822 | 0.92 | PDE4B (0.48) | PDE4BPDE7A | |
| Bicarbonate SCHEMBL583488 | 0.92 | PDE4B (0.51) | PDE4BPDE7APDE4D | |
| Bicarbonate SCHEMBL583625 | 0.92 | PDE4B (0.54) | PDE4BPDE7APDE4D | |
| Bicarbonate SCHEMBL583387 | 0.92 | PDE4B (0.54) | PDE4BPDE7APDE4D | |
| Bicarbonate SCHEMBL583185 | 0.92 | PDE4B (0.54) | PDE4BPDE7APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124944-B1 | Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors | RANBAXY LAB LTD (IN) | 2012-02-15 | — | — | EP | claimed |