⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936452 | 1.00 | — | — | |
| SCHEMBL8936395 | 1.00 | — | — | |
| SCHEMBL8936424 | 1.00 | — | — | |
| SCHEMBL8936459 | 1.00 | — | — | |
| SCHEMBL6617084 | 0.91 | — | — | |
| SCHEMBL16124355 | 0.76 | — | — | |
| SCHEMBL13527946 | 0.76 | — | — | |
| SCHEMBL8297426 | 0.73 | — | — | |
| SCHEMBL9171155 | 0.70 | — | — | |
| SCHEMBL8768730 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1517910-A1 | PHOSPHORAMIDITES FOR COUPLING OLIGONUCLEOTIDES TO (2 + 2) PHOTOREACTIVE GROUPS | Amersham Biosciences AB (SE) | 2005-03-30 | — | — | EP | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2004002995-A1 | PHOSPHORAMIDITES FOR COUPLING OLIGONUCLEOTIDES TO [2 + 2] PHOTOREACTIVE GROUPS | AMERSHAM BIOSCIENCES AB (SE) | 2004-01-08 | — | — | WO | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |
| US-20030096265-A1 | Phosphoramidites for coupling oligonucleotides to [2 + 2] photoreactive groups | MOTOROLA, INC. | 2003-05-22 | — | — | US | disclosed |