Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.58 |
| ▸ | KDR | P35968 | 6/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | CSK | P41240 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | FLT1 | P17948 | 3/20 | 0.54 |
| ▸ | FLT4 | P35916 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KIF5B | P33176 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828623 | 1.00 | EGFR (0.58) | EGFRKDRSRCCSKTEK | |
| SCHEMBL4691264 | 0.92 | EGFR (0.61) | EGFRKDRSRCCSKTEK | |
| SCHEMBL6980090 | 0.91 | EGFR (0.60) | EGFRKDRSRCCSKTEK | |
| SCHEMBL5498170 | 0.86 | EGFR (0.64) | EGFRKDRSRCCSKTEK | |
| SCHEMBL4686372 | 0.86 | EGFR (0.64) | EGFRKDRSRCCSKTEK | |
| SCHEMBL4430065 | 0.81 | EGFR (0.68) | EGFRKDRSRCCSKTEK | |
| SCHEMBL4689388 | 0.81 | EGFR (0.68) | EGFRKDRSRCCSKTEK | |
| SCHEMBL4423483 | 0.80 | EGFR (0.62) | EGFRKDRSRCCSKTEK | |
| SCHEMBL4427825 | 0.80 | EGFR (0.62) | EGFRKDRSRCCSKTEK | |
| SCHEMBL5496194 | 0.80 | KDR (0.67) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | claimed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |