Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 5/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 12/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | KIF5B | P33176 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427825 | 0.87 | EGFR (0.62) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL4689353 | 0.87 | KDR (0.55) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL4692095 | 0.83 | EGFR (0.52) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL4690872 | 0.83 | EGFR (0.58) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL4693103 | 0.82 | EGFR (0.58) | EPHA2EPHB4KDREGFRRET | |
| SCHEMBL4686372 | 0.82 | EGFR (0.64) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL5496194 | 0.81 | KDR (0.67) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL4687812 | 0.80 | EGFR (0.46) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL4690909 | 0.80 | EGFR (0.46) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL3131165 | 0.79 | EGFR (0.75) | EPHA2EPHB4ERBB2KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |