Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.50 |
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.49 |
| ▸ | FLT4 | P35916 | 4/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828734 | 1.00 | KDR (0.50) | KDREGFRPDGFRBFLT4CSF1R | |
| SCHEMBL5828198 | 1.00 | KDR (0.50) | KDREGFRPDGFRBFLT4CSF1R | |
| SCHEMBL5828927 | 0.91 | PDGFRB (0.46) | KDREGFRPDGFRBFLT4CSF1R | |
| SCHEMBL5828930 | 0.91 | PDGFRB (0.46) | KDREGFRPDGFRBFLT4CSF1R | |
| SCHEMBL5828257 | 0.88 | PDGFRB (0.52) | KDREGFRPDGFRBFLT4CSF1R | |
| SCHEMBL5828263 | 0.88 | PDGFRB (0.52) | KDREGFRPDGFRBFLT4CSF1R | |
| SCHEMBL5828886 | 0.84 | PDGFRB (0.49) | KDREGFRPDGFRBFLT4CSF1R | |
| SCHEMBL5828882 | 0.84 | PDGFRB (0.49) | KDREGFRPDGFRBFLT4CSF1R | |
| SCHEMBL5828691 | 0.82 | EGFR (0.52) | KDREGFRPDGFRBRETBRAF | |
| SCHEMBL5828689 | 0.82 | EGFR (0.52) | KDREGFRPDGFRBRETBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |