Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.60 |
| ▸ | WEE1 | P30291 | 10/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 5/20 | 0.51 |
| ▸ | CCND1 | P24385 | 4/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.49 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827590 | 0.83 | CHEK1 (0.55) | PDGFRBROCK2WEE1CHEK1ALDH1A1 | |
| SCHEMBL5828892 | 0.81 | PDGFRB (0.69) | PDGFRBROCK2WEE1CHEK1KDM4E | |
| SCHEMBL5828186 | 0.81 | PDGFRB (0.69) | PDGFRBROCK2WEE1CHEK1KDM4E | |
| Gw296115X SCHEMBL8120713 | 0.79 | PDGFRB (1.00) | PDGFRBROCK2WEE1CHEK1KDM4E | |
| Gw296115X SCHEMBL31281911 | 0.79 | PDGFRB (1.00) | PDGFRBROCK2WEE1CHEK1KDM4E | |
| SCHEMBL5829250 | 0.78 | PDGFRB (0.68) | PDGFRBROCK2WEE1CHEK1KDM4E | |
| SCHEMBL5827986 | 0.77 | WEE1 (0.77) | PDGFRBROCK2WEE1CHEK1TDP1 | |
| SCHEMBL5829173 | 0.77 | WEE1 (0.77) | PDGFRBROCK2WEE1CHEK1CDK2 | |
| SCHEMBL5829097 | 0.76 | WEE1 (0.76) | PDGFRBROCK2WEE1CHEK1CDK2 | |
| SCHEMBL5828682 | 0.76 | WEE1 (0.83) | PDGFRBROCK2WEE1CHEK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |