Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7782831 | 0.96 | CYP19A1 (0.42) | SLC6A2SLC6A4HIF1ASNCACYP19A1 | |
| Bromide SCHEMBL6442757 | 0.85 | HIF1A (0.40) | SLC6A2SLC6A4HIF1ASNCAALDH1A1 | |
| Bromide SCHEMBL4179333 | 0.81 | HIF1A (0.40) | HIF1ASNCAALDH1A1TSHRMAOB | |
| Bromide SCHEMBL2446627 | 0.80 | HIF1A (0.55) | SLC6A2SLC6A4HIF1ASNCAALDH1A1 | |
| Hydrochloric Acid SCHEMBL9292231 | 0.75 | HIF1A (0.55) | SLC6A2SLC6A4HIF1ASNCAALDH1A1 | |
| Bromide SCHEMBL8464686 | 0.74 | HIF1A (0.48) | HIF1ASNCAALDH1A1TSHRDPP4 | |
| SCHEMBL7382769 | 0.73 | CYP1A2 (0.50) | SLC6A2SLC6A4TSHRFFAR1MAOB | |
| Bromide SCHEMBL4287071 | 0.72 | HIF1A (0.46) | HIF1ASNCAALDH1A1MAPTTSHR | |
| Bromide SCHEMBL2451357 | 0.71 | HIF1A (0.44) | SLC6A2SLC6A4HIF1ASNCAALDH1A1 | |
| Bromide SCHEMBL4175689 | 0.71 | HIF1A (0.44) | SLC6A2SLC6A4HIF1ASNCAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |
| WO-1994011378-A1 | ARYL THIOPYRANO[2,3,4-c,d]INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-05-26 | — | — | WO | disclosed |
| US-5314900-A | Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1994-05-24 | — | — | US | disclosed |
| EP-0339126-B1 | Fluorelastomer compositions containing a tetraalkylammonium halide and vulcanization accelerator | DU PONT (US) | 1993-11-24 | — | — | EP | disclosed |
| US-4925892-A | ADHESION STRENGTH WHEN CURED; MIXING WITH PHOSPHONIUM SALT AND CROSSLINKING AGENT | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-15 | — | — | US | disclosed |
| EP-0339126-A1 | Fluorelastomer compositions containing a tetraalkylammonium halide and vulcanization accelerator | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4868234-A | IMPROVED ADHESION TO METAL | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0127484-B1 | CURABLE FLUOROPOLYMER CONTAINING AROMATIC AMINE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0127318-B1 | CURABLE FLUOROPOLYMER COMPOSITION | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0140207-A2 | A process for rapidly curing a brominated fluoroelastomer | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-05-08 | — | — | EP | disclosed |
| US-4496682-A | TWO-STAGE CURING WITH BISPHENOLS, BISAMINES, QUATERNARY AMMONIUM OR PHOSPHONIUM COMPONENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-01-29 | — | — | US | disclosed |
| US-4489196-A | CONTAINING VULCANIZATION ACCELERATOR, CROSSLINKING AGENT, METAL OXIDE OR HYDROXIDE, AND POLYOL COACCELERATOR | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-12-18 | — | — | US | disclosed |
| EP-0127484-A2 | Curable fluoropolymer containing aromatic amine | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-12-05 | — | — | EP | disclosed |
| EP-0127318-A1 | Curable fluoropolymer composition | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-12-05 | — | — | EP | disclosed |