Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 18/20 | 1.00 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.76 |
| ▸ | JAK2 | O60674 | 1/20 | 0.76 |
| ▸ | PAK4 | O96013 | 1/20 | 0.76 |
| ▸ | ABL1 | P00519 | 1/20 | 0.76 |
| ▸ | LCK | P06239 | 1/20 | 0.76 |
| ▸ | FYN | P06241 | 1/20 | 0.76 |
| ▸ | PIM1 | P11309 | 1/20 | 0.76 |
| ▸ | PRKACA | P17612 | 1/20 | 0.76 |
| ▸ | CDK2 | P24941 | 1/20 | 0.76 |
| ▸ | LTK | P29376 | 1/20 | 0.76 |
| ▸ | KDR | P35968 | 1/20 | 0.76 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.76 |
| ▸ | SYK | P43405 | 1/20 | 0.76 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.76 |
| ▸ | GSK3A | P49840 | 1/20 | 0.76 |
| ▸ | GSK3B | P49841 | 1/20 | 0.76 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.76 |
| ▸ | PRKX | P51817 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829159 | 0.91 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5829035 | 0.90 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5828678 | 0.88 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5828870 | 0.86 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5828632 | 0.86 | CHEK1 (0.76) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL29521464 | 0.86 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5828030 | 0.86 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5829344 | 0.85 | WEE1 (0.81) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5828611 | 0.85 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5828538 | 0.84 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | claimed |
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |