Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 18/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 16/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827923 | 0.90 | WEE1 (0.69) | WEE1CHEK1ROCK2PDGFRB | |
| SCHEMBL9832534 | 0.85 | WEE1 (0.78) | WEE1CHEK1 | |
| SCHEMBL5828676 | 0.85 | WEE1 (0.84) | WEE1CHEK1 | |
| SCHEMBL5827790 | 0.84 | WEE1 (1.00) | WEE1CHEK1 | |
| SCHEMBL5829093 | 0.84 | WEE1 (0.78) | WEE1CHEK1ROCK2PDGFRB | |
| SCHEMBL5827976 | 0.83 | WEE1 (0.77) | WEE1CHEK1ROCK2PDGFRB | |
| SCHEMBL5828158 | 0.83 | WEE1 (0.77) | WEE1CHEK1ROCK2PDGFRB | |
| SCHEMBL5829173 | 0.83 | WEE1 (0.77) | WEE1CHEK1ROCK2PDGFRB | |
| SCHEMBL5827986 | 0.83 | WEE1 (0.77) | WEE1CHEK1ROCK2PDGFRB | |
| SCHEMBL5827617 | 0.82 | WEE1 (0.74) | WEE1CHEK1ROCK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |