Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 0.77 |
| ▸ | CHEK1 | O14757 | 17/20 | 0.77 |
| ▸ | CDK1 | P06493 | 3/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835028 | 0.87 | WEE1 (0.77) | WEE1CHEK1CDK1 | |
| SCHEMBL5828081 | 0.87 | CHEK1 (1.00) | WEE1CHEK1CDK1CCNB1 | |
| SCHEMBL5828569 | 0.87 | WEE1 (0.77) | WEE1CHEK1CDK1CCNB1 | |
| SCHEMBL5828251 | 0.85 | WEE1 (0.74) | WEE1CHEK1CDK1CCNB1 | |
| SCHEMBL5827736 | 0.84 | WEE1 (0.72) | WEE1CHEK1CDK1 | |
| SCHEMBL5828848 | 0.83 | WEE1 (0.71) | WEE1CHEK1CDK1CCNB1 | |
| SCHEMBL5829489 | 0.83 | WEE1 (0.71) | WEE1CHEK1CDK1CCNB1 | |
| SCHEMBL5829852 | 0.83 | WEE1 (0.74) | WEE1CHEK1CDK1CCNB1 | |
| SCHEMBL5829850 | 0.82 | WEE1 (0.70) | WEE1CHEK1CDK1CCNB1 | |
| SCHEMBL5829561 | 0.82 | WEE1 (0.64) | WEE1CHEK1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |