Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.43 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831062 | 1.00 | PDE5A (0.43) | PDE5APDE6CPDE11APOLBSMN1; SMN2 | |
| SCHEMBL5261461 | 0.93 | PDE5A (0.44) | PDE5APDE6CPDE11A | |
| SCHEMBL5831059 | 0.88 | PDE5A (0.43) | PDE5APDE6C | |
| SCHEMBL5830570 | 0.88 | PDE5A (0.43) | PDE5APDE6C | |
| SCHEMBL5265806 | 0.88 | PDE5A (0.46) | PDE5APOLBSMN1; SMN2 | |
| SCHEMBL5261708 | 0.88 | PDE5A (0.46) | PDE5APOLBSMN1; SMN2 | |
| SCHEMBL5827978 | 0.86 | PDE5A (0.55) | PDE5A | |
| SCHEMBL5260459 | 0.82 | PDE5A (0.39) | PDE5A | |
| SCHEMBL5260296 | 0.82 | PDE5A (0.55) | PDE5APDE6CPDE11A | |
| SCHEMBL5259471 | 0.81 | PDE5A (0.54) | PDE5APDE6CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060824-B2 | Pyrrolotriazolopyrimidinone derivatives | ALMIRALL PRODESFARMA, S.A. (ES) | 2006-06-13 | — | — | US | disclosed |