SCHEMBL583181

SCHEMBL583181

O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)C1=CC(Cl)=CCC1=S

nearest known ligand 0.67

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.67
ABCB11 O95342 1/20 0.65
F2 P00734 1/20 0.65
ST14 Q9Y5Y6 1/20 0.65
CYP1A2 P05177 1/20 0.60
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2C9 P11712 1/20 0.60
CYP2C19 P33261 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3142337 1.00 F10 (0.67) F10ABCB11F2ST14CYP1A2
SCHEMBL3142323 0.91 F10 (0.59) F10ABCB11F2ST14CYP1A2
SCHEMBL3150504 0.91 F10 (0.62) F10ABCB11F2ST14
SCHEMBL3151258 0.91 F10 (0.55) F10ABCB11F2ST14CYP1A2
SCHEMBL3151478 0.91 F10 (0.58) F10ABCB11F2ST14CYP1A2
SCHEMBL3150382 0.91 F10 (0.68) F10ABCB11F2ST14CYP1A2
SCHEMBL3151508 0.90 F10 (0.69) F10ABCB11F2ST14
SCHEMBL3155737 0.90 F10 (0.65) F10ABCB11F2ST14CYP1A2
SCHEMBL3142255 0.90 F10 (0.67) F10ABCB11F2ST14CYP1A2
SCHEMBL3155698 0.90 F10 (0.56) F10ABCB11F2ST14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2099453-B1 Combination therapy of substituted oxazolidinones BAYER IP GMBH (DE) 2017-09-06 EP claimed
EP-2560964-A1 PROCESS FOR PREPARING 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Euticals GmbH (DE) 2013-02-27 EP claimed
WO-2011131316-A1 PROCESS FOR PREPARING 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE ARCHIMICA GMBH (DE) 2011-10-27 WO claimed
EP-1720866-B1 PRODUCTION METHOD BAYER SCHERING PHARMA AG (DE) 2011-08-03 EP claimed
JP-4667044-B2 2011-04-06 JP claimed
EP-1583761-B1 METHOD FOR PRODUCING 5-CHLORO- i N /i -({5 i S /i )-2-OXO-3- 4-(3-OXO-4-MORPHOLINYL)-PHENYL -1,3-OXAZOLIDIN-5-YL&rc ub;-METHYL)-2-THIOPHENE CARBOXAMIDE BAYER SCHERING PHARMA AG (DE) 2011-02-23 EP claimed
EP-1411932-B1 SUBSTITUTED OXAZOLIDINONES FOR COMBINATIONAL THERAPY BAYER SCHERING PHARMA AG (DE) 2010-02-10 EP claimed
US-20100003542-A1 Coating of artificial surfaces of medical aids and instruments, and cleaning and/or pretreatment of catheters and other medical aids and instruments BAYER SCHERING PHARMA AKTIENGESSELSCHAFT (DE) 2010-01-07 US claimed
US-20090075949-A1 Use of dipyridamole in combination with antithrombotics for treatment and prevention of thromboembolic diseases EISERT WOLFGANG 2009-03-19 US claimed
EP-1807086-A1 USE OF DIPYRIDAMOLE IN COMBINATION WITH ANTITHROMBOTICS FOR TREATMENT AND PREVENTION OF THROMBOEMBOLIC DISEASES Boehringer Ingelheim International GmbH (DE) 2007-07-18 EP claimed
JP-2007517816-A 2007-07-05 JP claimed
EP-1720866-A1 PRODUCTION METHOD Bayer HealthCare AG (DE) 2006-11-15 EP claimed
WO-2006045756-A1 USE OF DIPYRIDAMOLE IN COMBINATION WITH ANTITHROMBOTICS FOR TREATMENT AND PREVENTION OF THROMBOEMBOLIC DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-05-04 WO claimed
JP-2006513227-A 2006-04-20 JP claimed
EP-1583761-A1 METHOD FOR PRODUCING 5-CHLORO- i N /i -({5 i S /i )-2-OXO-3- 4-(3-OXO-4-MORPHOLINYL)-PHENYL -1,3-OXAZOLIDIN-5-YL&rc ub;-METHYL)-2-THIOPHENE CARBOXAMIDE Bayer HealthCare AG (DE) 2005-10-12 EP claimed
WO-2005068456-A1 PRODUCTION METHOD BAYER HEALTHCARE AG (DE) 2005-07-28 WO claimed
WO-2004060887-A1 METHOD FOR PRODUCING 5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)-PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2-THIOPHENE CARBOXAMIDE BAYER HEALTHCARE AG (DE) 2004-07-22 WO claimed
EP-2099453-B1 Combination therapy of substituted oxazolidinones BAYER IP GMBH (DE) 2017-09-06 EP disclosed
EP-1261606-A1 SUBSTITUTED OXAZOLIDINONES AND THEIR USE IN THE FIELD OF BLOOD COAGULATION Bayer Aktiengesellschaft (DE) 2002-12-04 EP disclosed
WO-2001047919-A1 SUBSTITUTED OXAZOLIDINONES AND THEIR USE IN THE FIELD OF BLOOD COAGULATION BAYER AKTIENGESELLSCHAFT (DE) 2001-07-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090075949-A1 Use of dipyridamole in combination with antithrombotics for treatment and prevention of thromboembolic diseases PEPD, PLAT, TFPI F10 51/4885ABCB11 1508/4885F2 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.