Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831945 | 0.88 | NPC1 (0.64) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5832250 | 0.81 | NPC1 (0.62) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5833322 | 0.80 | NPC1 (0.65) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5832760 | 0.79 | NPC1 (0.71) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5832858 | 0.79 | NPC1 (0.67) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL660569 | 0.77 | NPC1 (0.67) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL28436509 | 0.76 | NPC1 (1.00) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5832162 | 0.76 | NPC1 (0.59) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5832925 | 0.76 | NPC1 (0.59) | NPC1TP53TSHRHSD17B10ALDH1A1 | |
| SCHEMBL5832117 | 0.76 | NPC1 (0.59) | NPC1TP53HSD17B10ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087601-B2 | Metabotropic glutamate receptor-5 modulators | MERCK & CO., INC. (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1453815-A4 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-20050065340-A1 | Metabotropic glutamate receptor-5 modulators | MERCK SHARP & DOHME CORP. | 2005-03-24 | — | — | US | disclosed |
| EP-1453815-A1 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | Merck & Co., Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | disclosed |
| WO-2003048137-A1 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | MERCK & CO., INC. (US) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065340-A1 | Metabotropic glutamate receptor-5 modulators | GRM5, GRIK5, GRM1 | NPC1 3080/4885TP53 4829/4885TSHR 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.