Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | STAT1 | P42224 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11320611 | 0.88 | NPC1 (0.59) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL3317791 | 0.84 | KDM6B (0.63) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL2493904 | 0.82 | NPC1 (0.64) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL11697224 | 0.82 | NPC1 (0.59) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL5832955 | 0.82 | MAPT (0.63) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL5831975 | 0.82 | NPC1 (0.68) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL11326576 | 0.81 | NPC1 (0.55) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL30959735 | 0.81 | NPC1 (0.53) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL10069500 | 0.80 | NPC1 (0.60) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL5832580 | 0.79 | NPC1 (0.79) | NPC1RAB9AALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087601-B2 | Metabotropic glutamate receptor-5 modulators | MERCK & CO., INC. (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1453815-A4 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-20050065340-A1 | Metabotropic glutamate receptor-5 modulators | MERCK SHARP & DOHME CORP. | 2005-03-24 | — | — | US | disclosed |
| EP-1453815-A1 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | Merck & Co., Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | disclosed |
| WO-2003048137-A1 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | MERCK & CO., INC. (US) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065340-A1 | Metabotropic glutamate receptor-5 modulators | GRM5, GRIK5, GRM1 | NPC1 3080/4885RAB9A 1104/4885ALDH1A1 2908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.