Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878700 | 1.00 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3880400 | 0.93 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3884596 | 0.91 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3883786 | 0.91 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3886651 | 0.90 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3886641 | 0.86 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3882742 | 0.86 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3876330 | 0.86 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3874224 | 0.85 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3877323 | 0.85 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622610-B1 | 1-(2H-PYRAZOL-3-YL)-3-{4-[1-(BENZOYL)-PIPERIDIN-4-YLMETHYL]-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AVENTIS PHARMA INC (US) | 2006-12-20 | — | — | EP | disclosed |