Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL582429 | 0.99 | PDE4B (0.46) | PDE4BPDE7AABL1BCRALK | |
| SCHEMBL582190 | 0.92 | PDE4B (0.48) | PDE4BPDE7AABL1BCRPDE3B | |
| SCHEMBL583252 | 0.92 | PDE4B (0.48) | PDE4BPDE7AABL1BCRPDE3B | |
| SCHEMBL582884 | 0.91 | PDE4B (0.48) | PDE4BPDE7AABL1BCRPDE3B | |
| SCHEMBL582254 | 0.88 | PDE4B (0.48) | PDE4BPDE7AABL1BCRALK | |
| SCHEMBL583087 | 0.88 | PDE4B (0.45) | PDE4BPDE7AABL1BCRPDE3B | |
| SCHEMBL582855 | 0.87 | PDE4B (0.48) | PDE4BPDE7AABL1BCRPDE3B | |
| SCHEMBL583133 | 0.86 | PDE4B (0.46) | PDE4BPDE7APDE3BPDE3ASRC | |
| SCHEMBL583099 | 0.86 | PDE4B (0.46) | PDE4BPDE7AALDH1A1 | |
| SCHEMBL583423 | 0.86 | PDE4B (0.46) | PDE4BPDE7AABL1BCRPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124944-B1 | Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors | RANBAXY LAB LTD (IN) | 2012-02-15 | — | — | EP | claimed |