Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.56 |
| ▸ | CDK2 | P24941 | 7/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835654 | 1.00 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5835993 | 0.83 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5835780 | 0.82 | CDK2 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27550543 | 0.78 | CDK2 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27569831 | 0.78 | CDK2 (0.70) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5836593 | 0.78 | CDK2 (0.70) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27549752 | 0.76 | CDK2 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5835703 | 0.75 | CDK2 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27549761 | 0.75 | CDK2 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5835698 | 0.74 | CDK2 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |