Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | SETD1B | Q9UPS6 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835960 | 0.87 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL5835589 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL17353987 | 0.77 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL5842781 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL5835735 | 0.75 | SMN1; SMN2 (0.83) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL27780255 | 0.73 | CCNE1 (0.71) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL5836346 | 0.73 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL28405114 | 0.72 | CA12 (0.50) | SMN1; SMN2MAPK10CCNE1CDK2CDK1 | |
| SCHEMBL6729 | 0.70 | CCNE1 (0.59) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL29003794 | 0.70 | MAPT (0.55) | SMN1; SMN2CCNE1CDK2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | disclosed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | disclosed |