Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.65 |
| ▸ | CDK2 | P24941 | 5/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5836176 | 0.95 | CCNE1 (0.65) | CCNE1CDK2CDK5CHRNB2CHRNA4 | |
| SCHEMBL5836073 | 0.90 | CCNE1 (0.68) | CCNE1CDK2CDK5RAB9AALDH1A1 | |
| SCHEMBL5835991 | 0.85 | CCNE1 (0.71) | CCNE1CDK2CDK5RAB9ANPC1 | |
| SCHEMBL5835583 | 0.84 | CCNE1 (0.70) | CCNE1CDK2CDK5RAB9AALDH1A1 | |
| SCHEMBL5835407 | 0.83 | CCNE1 (0.72) | CCNE1CDK2CDK5RAB9AALDH1A1 | |
| SCHEMBL5836464 | 0.82 | CCNE1 (0.79) | CCNE1CDK2CDK5RAB9AALDH1A1 | |
| SCHEMBL5835793 | 0.82 | CDK2 (0.67) | CCNE1CDK2CDK5RAB9AALDH1A1 | |
| SCHEMBL5835456 | 0.81 | CDK2 (0.73) | CCNE1CDK2CDK5RAB9AALDH1A1 | |
| SCHEMBL5835808 | 0.81 | CCNE1 (0.65) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL5835438 | 0.81 | CCNE1 (0.65) | CCNE1CDK2CDK5RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | claimed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | claimed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | claimed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | disclosed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |