Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 4/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5832808 | 0.93 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3880808 | 0.92 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3874719 | 0.90 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3887738 | 0.88 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3887721 | 0.88 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3874422 | 0.87 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3875428 | 0.87 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL3877358 | 0.87 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3879435 | 0.87 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL3874647 | 0.86 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622610-B1 | 1-(2H-PYRAZOL-3-YL)-3-{4-[1-(BENZOYL)-PIPERIDIN-4-YLMETHYL]-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AVENTIS PHARMA INC (US) | 2006-12-20 | — | — | EP | disclosed |