Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 6/20 | 0.72 |
| ▸ | CDK2 | P24941 | 6/20 | 0.72 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.72 |
| ▸ | STAT3 | P40763 | 1/20 | 0.62 |
| ▸ | GCK | P35557 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.53 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.53 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835385 | 0.87 | CDK2 (0.67) | CCNE1CDK2CDK5STAT3ALDH1A1 | |
| SCHEMBL5835970 | 0.86 | CCNE1 (0.74) | CCNE1CDK2CDK5ALDH1A1NPC1 | |
| SCHEMBL5835431 | 0.85 | CCNE1 (0.72) | CCNE1CDK2CDK5GRM5ALDH1A1 | |
| SCHEMBL5835428 | 0.85 | CDK2 (0.72) | CCNE1CDK2CDK5STAT3GRM5 | |
| SCHEMBL5835396 | 0.85 | CCNE1 (0.72) | CCNE1CDK2CDK5KCNQ3KCNQ2 | |
| SCHEMBL5835708 | 0.84 | CDK2 (0.75) | CCNE1CDK2CDK5STAT3ALDH1A1 | |
| SCHEMBL5836102 | 0.84 | CDK2 (1.00) | CCNE1CDK2CDK5ALDH1A1NPC1 | |
| SCHEMBL5836194 | 0.84 | CDK2 (0.66) | CCNE1CDK2CDK5STAT3KCNQ3 | |
| SCHEMBL5836282 | 0.83 | CCNE1 (0.69) | CCNE1CDK2CDK5KCNQ3KCNQ2 | |
| SCHEMBL5835918 | 0.83 | CCNE1 (0.69) | CCNE1CDK2CDK5ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | claimed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | claimed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | claimed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | disclosed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |