Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.61 |
| ▸ | BRD2 | P25440 | 6/20 | 0.61 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837407 | 1.00 | BRD4 (0.61) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL5837410 | 1.00 | BRD4 (0.61) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL6586899 | 1.00 | BRD4 (0.61) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL5836769 | 1.00 | BRD4 (0.61) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL4126285 | 0.90 | BRD4 (0.74) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL5836704 | 0.90 | BRD4 (0.74) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL4129055 | 0.90 | BRD4 (0.74) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL4122671 | 0.90 | BRD4 (0.74) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL221987 | 0.90 | BRD4 (0.74) | BRD4BRD2BRD3LMNAGFER | |
| SCHEMBL224566 | 0.89 | BRD4 (0.65) | BRD4BRD2BRD3LMNAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030246-B2 | Tetrahydroquinoline derivatives as stat6-modulators, preparation and use thereof | ASTRAZENECA AB (SE) | 2006-04-18 | — | — | US | disclosed |
| US-20040132724-A1 | Tetrahydroquinoline derivatives as stat6-modulators, preparation and use thereof | ASTRAZENECA AB (SE) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132724-A1 | Tetrahydroquinoline derivatives as stat6-modulators, preparation and use thereof | STAT6, HRH4, HRH1 | BRD4 39/4885BRD2 153/4885BRD3 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.