Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.57 |
| ▸ | CDK2 | P24941 | 5/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.57 |
| ▸ | ENPP1 | P22413 | 6/20 | 0.56 |
| ▸ | ENPP3 | O14638 | 5/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835708 | 0.86 | CDK2 (0.75) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL5836145 | 0.80 | CDK2 (0.70) | CCNE1CDK2CDK5MEN1KMT2A | |
| SCHEMBL5836066 | 0.79 | CDK2 (0.68) | CCNE1CDK2CDK5MEN1KMT2A | |
| SCHEMBL5835991 | 0.79 | CCNE1 (0.71) | CCNE1CDK2CDK5MEN1KMT2A | |
| SCHEMBL5835583 | 0.78 | CCNE1 (0.70) | CCNE1CDK2CDK5MAPTCSNK2A2 | |
| SCHEMBL5836120 | 0.77 | CDK2 (0.77) | CCNE1CDK2CDK5STAT3MEN1 | |
| SCHEMBL5836073 | 0.77 | CCNE1 (0.68) | CCNE1CDK2CDK5MEN1KMT2A | |
| SCHEMBL5836464 | 0.76 | CCNE1 (0.79) | CCNE1CDK2CDK5MEN1KMT2A | |
| SCHEMBL5835793 | 0.76 | CDK2 (0.67) | CCNE1CDK2CDK5MEN1KMT2A | |
| SCHEMBL5835456 | 0.75 | CDK2 (0.73) | CCNE1CDK2CDK5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | claimed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | claimed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | disclosed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | disclosed |