Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583234 | 1.00 | PDE4B (0.51) | PDE4BHTTADORA1PDE3BPDE7A | |
| SCHEMBL583235 | 1.00 | PDE4B (0.51) | PDE4BHTTADORA1PDE3BPDE7A | |
| SCHEMBL583577 | 0.96 | PDE4B (0.54) | PDE4BHTTADORA1 | |
| SCHEMBL1472464 | 0.96 | PDE4B (0.54) | PDE4BHTTADORA1 | |
| SCHEMBL1471895 | 0.91 | PDE4B (0.60) | PDE4BHTT | |
| SCHEMBL583013 | 0.91 | PDE4B (0.60) | PDE4BHTT | |
| SCHEMBL582653 | 0.90 | PDE4B (0.60) | PDE4B | |
| SCHEMBL582654 | 0.90 | PDE4B (0.60) | PDE4B | |
| SCHEMBL583314 | 0.88 | PDE4B (0.65) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL582258 | 0.88 | PDE4B (0.65) | PDE4BPDE3BPDE7APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124944-B1 | Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors | RANBAXY LAB LTD (IN) | 2012-02-15 | — | — | EP | claimed |