Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 18/20 | 0.42 |
| ▸ | RAB7A | P51149 | 2/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 10/20 | 0.40 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | PTPRB | P23467 | 2/20 | 0.40 |
| ▸ | PTPRE | P23469 | 2/20 | 0.40 |
| ▸ | PTPRA | P18433 | 2/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843333 | 0.80 | PTPN1 (0.49) | PTPN1PTPN2PTPRCPTPRBPTPRE | |
| SCHEMBL6207147 | 0.79 | PTPN1 (0.51) | PTPN1RAB7APTPN2PTPRCPTPRB | |
| SCHEMBL6205853 | 0.78 | PTPN1 (0.44) | PTPN1RAB7APTPN2PTPRCPTPRB | |
| SCHEMBL5838812 | 0.76 | PTPN1 (0.46) | PTPN1RAB7APTPN2PTPRCPTPRB | |
| SCHEMBL6207812 | 0.75 | PTPN1 (0.47) | PTPN1RAB7APTPN2PTPRCPTPRB | |
| SCHEMBL6322684 | 0.75 | PTPN1 (0.46) | PTPN1RAB7APTPN2PTPRCPTPRB | |
| SCHEMBL7676326 | 0.74 | PTPN1 (0.49) | PTPN1RAB7APTPN2PTPRCPTPRB | |
| SCHEMBL6314433 | 0.74 | PTPN1 (0.46) | PTPN1RAB7APTPN2PTPRCPTPRB | |
| SCHEMBL6314421 | 0.74 | PTPN1 (0.54) | PTPN1RAB7APTPN2PTPRCPTPRB | |
| SCHEMBL6323723 | 0.74 | PTPN1 (0.46) | PTPN1RAB7APTPN2PTPRCPTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | claimed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | claimed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | claimed |
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |