Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583682 | 0.93 | PDE4B (0.43) | PDE4BPDE7APDE3BPDE3AADORA1 | |
| SCHEMBL582909 | 0.92 | PDE4B (0.51) | PDE4BPDE7A | |
| SCHEMBL582885 | 0.91 | PDE4B (0.53) | PDE4BPDE7APDE3BPDE3A | |
| SCHEMBL583312 | 0.91 | PDE4B (0.42) | PDE4BPDE7APDE3BPDE3AADORA1 | |
| SCHEMBL583203 | 0.90 | PDE4B (0.44) | PDE4BPDE7APDE3BPDE3AADORA1 | |
| SCHEMBL582641 | 0.90 | PDE4B (0.44) | PDE4BPDE7APDE3BPDE3AADORA1 | |
| SCHEMBL582576 | 0.90 | PDE4B (0.42) | PDE4BPDE7APDE3BPDE3AADORA1 | |
| SCHEMBL582296 | 0.89 | PDE4B (0.44) | PDE4BPDE7APDE3BPDE3A | |
| SCHEMBL582505 | 0.89 | PDE4B (0.46) | PDE4BPDE7APDE3BPDE3A | |
| SCHEMBL583178 | 0.89 | PDE4B (0.43) | PDE4BPDE7APDE3BPDE3AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124944-B1 | Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors | RANBAXY LAB LTD (IN) | 2012-02-15 | — | — | EP | claimed |